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Jun 11, 2025 11:20 AM
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Apr 2023
516
WTF! Here I thought we can go back with Shisui
Jun 11, 2025 5:08 PM
Shalltear

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Apr 2018
37585
It was all fun when Maomao ate the snakes but Shenmei was awful and I didn't expect this very shocking end of episode with all the kids poisoned by Shisui.. I hope that they're not already dead
Jun 11, 2025 5:55 PM
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Jan 2013
8
I'm kind of confused with the direction of this episode, I feel like so many intense things happened but they were delivered quite dryly. Like, compare all the revelations in this to any episodic mystery until now. It feels like the edition and storyboard direction lacks impact. That being said, most likely that is because they needed to set up a lot of events faster to get to the big final episodes in the coming weeks, so Imma be charitable.

Like legit so many jaw dropping shit happened but so closely one after the other I got whiplash lol
Jun 12, 2025 10:24 PM
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Nov 2017
50
Damn that was heavy, I loved seeing into Shisui's heart and thought process more. She really is a merciful good girl who's forced into submission by her mother.
Jun 13, 2025 4:49 AM

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Apr 2015
50
Reply to LaczPro19
@SolLamia no. An actual delay according to AnimeSchedule

https://animeschedule.net/anime/kusuriya-no-hitorigoto-2nd-season

Episode 23 has been delayed by a week. Episode 22 will air on June 27th, 2025.

@LaczPro19 Hold on so this Friday 13th is there no episode? I'm confused, the link says it's ep 23 that will be on June 27th?

also this from the official Kusuriya site:
(Translated via Google Translate)
In addition, a special anime music video for the opening theme of the second season, the second cool, Mrs. GREEN APPLE 's "Kusushiki" will be premiered on the TOHO animation official YouTube channel from 23:30 on Friday, June 13th, immediately after the broadcast of episode 46!

Original:
さらに、第46話の放送直後となる6月13日(金)23:30より、TOHO animation 公式YouTubeチャンネルにて、第2期 第2クールのオープニングテーマ Mrs. GREEN APPLE「クスシキ」のスペシャルアニメMVをプレミア公開いたします!

From here tho what I'm getting is, there's an episode this Friday as well as showing specials on Youtube? Sorry just confused which episode is delayed

Link to official site with the news
Jun 13, 2025 5:04 AM

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Apr 2015
50
Reply to LaczPro19
@SolLamia I messed up. In reality, next week is ep 22, June 20th no episode, June 27th the 23rd episode and July 4th the final
@LaczPro19 Oh I see. Lol already made a post but I guess this clears this up. Thanks ^^,
Jun 13, 2025 9:05 AM

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Jul 2024
1703
Reply to SolLamia
@LaczPro19 Oh I see. Lol already made a post but I guess this clears this up. Thanks ^^,
@SolLamia yup. 10 minutes left for 22nd episode
©2026 LaczPro

What I said earlier might or might not have been serious. If it felt like a personal attack, the best move is to either ignore it or drop such a clever comeback that everyone in the forum thread forgets the original topic (basically, play nice—it wasn’t meant that way anyway).

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Jun 13, 2025 10:35 AM
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Jun 2021
91
kyou-u's smile... i want to cry :(
we're connected by the black thread of fate, after all
Jun 13, 2025 7:34 PM

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May 2015
2290
Everyone is fucking insane in this anime
It's time for Jinshi to clean up this mess
Jun 13, 2025 7:39 PM

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Jan 2022
2236
Code Geass got nothing on the political intrigue demonstrated here. And also, we'll see the climax of the resurrection medicine subplot soon. It's a really dark scene, but there's a ray of hope.

cameNmypants@reddit.com said:
Kita brings the sex,
Ryo the drugs,
and Bocchi the rock

(source)
Jun 14, 2025 8:55 AM
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Feb 2013
49
DAMN. that ending went from 0-100 real quick.
Jun 15, 2025 6:02 AM

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Nov 2023
2698
What an episode!

I hate shenmei so much!

Loulan why did do that? Nooooo....
Jun 15, 2025 7:28 PM

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Jul 2016
9875
Shisui letting workers escape: ✅
Shisui letting children escape: ❌
Also Shisui later realizing she could have just asked Xiaomao to intercede for the children since Xiaomao's on very good terms with both Jinshi and The Emperor:


And seriously, what an one-dimensional villain this Shenmei hag is. Not gonna lie, pretty disappointing coming from a show that constantly tries to humanize all its antagonists. Not to mention I still fail to understand why everyone are so willing to serve her when she's clearly a lost cause but well. Gotta guess it's because of Shishou being behind her and shit.
Jun 16, 2025 12:14 PM
🥊 CHAMPION 🥊

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Apr 2016
25619
Tragic final of episode, with the kill of the kids!!!
kekeke
Jun 17, 2025 8:27 AM
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Jun 2020
245
Damn poor kids. It was really a mercy killing is what I got from this, I don’t think they’ll come back unless she somehow preserves their bodies in all this chaos and save the lab from being destroyed.

I see where Jim Jones got his inspiration from.
Jun 17, 2025 10:16 AM

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Nov 2019
309
Cornered and without a way out.
All this because of one mad woman's revenge scheme.
Jun 18, 2025 3:43 PM
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Jun 2022
195
this episode is kinda fucked, i didn't expect Loulan to just end those kids, but it's for the better i guess since they'll eventually die because of the royal army..
Jun 19, 2025 6:22 PM
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Jul 2017
1187
whack episode, what show, i just need this to end pls
Jun 20, 2025 12:42 PM

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Jul 2017
18121
Maomao being in a position to create the next-to-impossible immortality potion, that even Loulan giggles with reassurance. But Kyou-u being ambitious to want to create an escape plan for Maomao, having Suirei deal with the issue is amicable enough, but that changes when Shenmei makes her appearance and chooses suffering everyone around her, and Maomao took one for the sake of others, that's for sure. But the Taibon, something which Suirei fears a lot, is not so much a punishment for the apothecary so used to insects and poison, but rather a benefit that surprises their close confidante of the guard all the more.

More than Maomao's escape plan, Loulan having to coerce the workers to literally make an escape for their lives, and shit just got real for the apothecary in a split second. Even to Loulan, she was also being mistreated like like a doll for her mother, and this became quite the family drama alongside the clearance of the grave of Taihou and others who were also once being chased out of the stronghold. A mixed-blood family as Loulan/Shisui implies with both Western and Eastern blood, but one still able to fool the people she loves in order to "save" them from facing calamity, like giving the kids poison (mixed with sweet juice) to drink.

What exactly is Loulan/Shisui's purpose in being her mother's "puppet", because this is clearly within her mother's realm of exploit unimaginable...
Jun 30, 2025 11:40 PM

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Dec 2020
1660
the ending ok my jaw is on the floor this is so sad. good episode
Jul 1, 2025 10:47 AM
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Jan 2025
6
What a plot twist, omg
Jul 3, 2025 12:20 PM

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May 2023
429
Damn I didn't expect that ending.

I understand why Shisui did it, after all the entire clan was going to get punished regarless of who did it or not. So in a way she did it humanily without them suffering, but still it ain't right. There had to be another way to save them, like maomao explaining to the rest that the kids were kidnapped or something along those lines to be able to save them. :-(

It breaks my heart seeing maomao so conflicted.
"Deceive yourself in every last detail... Deceive the world. Do this, and victory is assured. Best of luck to you, old friend. El... Psy... Congroo." -- Hououin Kyouma



Jul 3, 2025 4:01 PM
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Jul 2018
555862
What is going on with this anime! It suddenly turned into a masterpiece! Oh my god!

I’m not going to comment yet… I’m off to watch more. I’ll save my thoughts for later.

I think I’ll need to rewatch some episodes to connect all the dots… ahh. See you in Episode 22 comments.
Jul 4, 2025 9:08 AM
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Jan 2017
349
foda fi mataram as criança tudo para ficarem ligeira
Jul 5, 2025 2:57 AM
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Jan 2021
32
I WANT TO BEAT THAT SHENMEI UP OH MY GOD??? THAT WITCH!!!
I'm NOT suprised at all that Maomao consumed all of those- really!
I was so sad that Shisui repeatedly masked her emotions and unmasked them over and over while her and Maomao were talking BUT THEN SHE KILLED THOSE KIDS!!! WHAT????
I'm so angry, really.

Excited for new episodes/seasons! <3
Jul 7, 2025 2:38 AM

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Nov 2023
457
the episodes go by quick when its interesting. rip kyou-u
Jul 20, 2025 8:54 AM
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Dec 2024
198
I loved in this episode how Maomao pissed of this Shenmai. After she was send to the pit I was worried, but when she was seen eating snake I was just laughing. The reaction of the guard was so funny (but it was expectable that she would do such a thing ;)). I think this whole senery was absolutely great done. Also at the where Rakan and Ruomen are discussing and finally asking Jinji (in his true identity) to mobilize the forbidden army was epic to watch. In summary, I loved the episode. :D
Jul 28, 2025 11:05 AM

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Dec 2023
1549
After careful analysis and reviewing of the lineage with the emperor and his children, I still am absolutely baffled at everything going on. Loulan being Shishui, her KILLING THE CHILDREN because "they were gonna die anyway". Blasting the gunpowder room. How does that woman maintain composure??? The fact that even that horror episode tied back to her struggles in her family. These past 3 episodes have been an absolute thrill ride, tying all the information together so quickly that my head's going in circles. I don't even know what to say anymore.
"Like rowing a boat, we enter the future backwards. All we see are scenes of the past, and no one can control the views of tomorrow" - Wit Studio
Aug 8, 2025 2:09 AM

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Jul 2013
10609
I keep getting lost in the lore idk who's the daughter of who anymore lol half sister with that, bastard daughter with the sister-in-law of the son of the nephew of the previous emperor's cousin's maid bullshit lol
Aug 14, 2025 12:16 AM
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Apr 2024
418
o my god it so so interessant i have to finish this now
Aug 23, 2025 5:58 PM

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Feb 2009
479
This arc makes no sense. Crazy old woman who is somehow left alive despite no one liking her. Suirei has no issues trying to kill Jinshi or any of the other murders she was involved with in S1 leading up to that plot, but never tried to get rid of this old lady who treats her so badly and even threw out her mother. Yet everyone...Loulan, even Shishou who has considerable standing even in the palace just blindly marched on and does whatever she says, even if it meant their entire village would die for rebelling against the emperor. If Loulan wanted to thwart whatever her mother was doing, she could've easily just told the Emperor or Jinshi regarding their plan, instead she goes back and drags Maomao along for some god knows reason only to sabotage the rebellion when it was already too late and the Emperor's troops are already marching....She poisons the kids, but I assume that is the fake death medicine Suirei has been experimenting with to save the innocent villagers who would otherwise all die due to the rebellion. Otherwise it makes no sense at all...

That Suirei was able to sneak back in to the rear palace was crazy to begin with. Who the hell tests for eunuch by physically grabbing each person there by three different officials? It would've been much faster, more efficient, and sanitary to have them drop the pants...She wasn't even in much of a disguise and yet Jinshi got close to her without recognizing her despite recognizing a mole on 1 out of 50 court lady in Loulan's pavilion. The logic is really weak this season....
Aug 31, 2025 12:07 AM
scientia exitus

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Mar 2020
6582
Needed a family-tree diagram opened in another tab constantly while watching Dark. Apothecary Diaries is nowhere near as complicated of course, but dang I still need that family tree. Gotta admit that I'm still confused as how exactly Suirei is related to anybody, other than that she's Loulan's half-sister. I got that right at least... right??


NYANPASU
whiskey tango foxtrot

Oct 11, 2025 7:22 PM

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Jul 2016
30
Maomao is the coolest. That is all.
Oct 25, 2025 11:22 AM

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Jun 2014
22621
Well, things certainly got morbid. Maomao is torn between a rock and a hard place regarding Shisui.

Nov 20, 2025 10:52 PM

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May 2020
1259
Maomao pissed Shenmei, and Loulan suggested using Taibon as punishment. Loulan knew Maomao wouldn't have a problem with snakes, but didn't expect her to cook and eat them.

Loulan has the gunpowder workers leave and sets the gunpowder on fire. Loulan and Maomao go to a room with near dead or dead children, because as rebellions, they wouldn't be spared.
Dec 25, 2025 4:07 AM
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Mar 2023
58
The hole. An awfull death, luckily Maomao is one of the few people that are "immune" to it.
Jan 12, 3:42 PM

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Jun 2015
5311
She's gonna say "Would you commit suicide with me?" 😭
FUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUCK

Sometimes I have to remind myself that this isn't a shounen and there is no power of friendship.

I saw this elsewhere: Lakan loves and recognizes his daughter despite being unable to see faces, while Shenmei can see faces just fine but can't recognize her own daughter outside of the role she wants her in.

5/5
Feb 2, 11:06 PM

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Feb 2019
2949
the taibon torture backfired lol maomao had a feast of snake meat
but poor children. either way, they ended up gone before they were able to live out the rest of their lives.
Mar 3, 12:21 PM

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Oct 2019
1434
So what was the point of that supposed "rebellion" if they had zero chance of winning? I don't get it. As for Shisui/Loulan, she is bloody ruthless, isn't she?
May 31, 6:17 PM

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Mar 2020
291
Damn, so we're just killing off kids now, huh.

WATCH One Piece!

Holo & Roxy Supremacy
Jun 3, 6:37 AM
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May 2026
107
Yeah this arc isn't gonna have a happy ending is it 10/10
Jun 3, 6:39 AM
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May 2026
107
Yeah shou tucker got some competition for worst parent shisui's mother is neck and neck
Jun 8, 11:58 PM
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Jun 2020
1
ABSOLUTE CINEMA!
Sep 18, 10:21 PM

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Apr 2020
2752
It just goes to show that as we watch Maomao's limited POV, the story as it goes has fooled us for far too long. Which is why those perfumes that the "Consort Loulan" wears, the ghost story episode (that turns out wasn't a filler), and the Lantern Festival, all goes to Loulan's cry of her life under the tyranny of Shenmei. And poor Suirei, the mention of Taibon spells horror hour to her. But the ending man, it was a brutal landing for me. Kinda like what Star Wars did, but as we are ready to call her Shisui again, we get that scene. Tough.
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